Intrapersonal and social environment correlates of leisure-time physical activity for cancer prevention: a cross-sectional study among Canadian adults.

Intrapersonal and social environment correlates of leisure-time physical activity for cancer prevention: a cross-sectional study among Canadian adults. Journal: J Phys Act Health| Pages: 790-800 |Date: May 2014 | Authors: Aparicio-Ting FE, Friedenreich CM, Kopciuk KA, Plotnikoff RC, Bryant HE. BACKGROUND: Little is known about the intrapersonal and social factors associated with sufficient physical activity (PA) for cancer prevention, which is greater than for cardiovascular health. METHODS: 1087 and 1684 randomly selected men and women, age 35-64, completed self-administered questionnaires on PA behavior and psycho-social characteristics. Using gender-stratified logistic regression, we investigated correlates of compliance with Canadian Society for Exercise Physiology PA guidelines for general health (150 min/wk), and the American Cancer Society (ACS; 225 min/wk) and World Cancer Research Fund/American Institute for Cancer Research (WCRF/AIRC; 420 min/wk) guidelines for cancer prevention. RESULTS: Only 39% and 19% of men and women met ACS and WCRF/AICR guidelines, respectively. Self-efficacy, scheduling PA and friend social support were positively correlated with recommended PA for cancer prevention. In men, poor self-rated health and perceived negative outcomes were negatively correlated and hypertension was positively correlated with meeting cancer prevention guidelines. For women, not being married and having a companion for PA were positively correlated with meeting cancer prevention guidelines. CONCLUSIONS: Few adults participate in sufficient PA for cancer risk reduction. Multidimensional public health strategies that incorporate intrapersonal and social factors and are tailored for each gender are needed to promote PA for cancer prevention.   http://www.ncbi.nlm.nih.gov/pubmed/25078523

Leisure-time physical activity does not attenuate the association between occupational sedentary behaviour and obesity: Results from the Tomorrow Project in Alberta, Canada.

Leisure-time physical activity does not attenuate the association between occupational sedentary behaviour and obesity: Results from the Tomorrow Project in Alberta, Canada. Journal: J.Phys.Act.Health | Date: April 2015 | Authors: Nicholas JA, Lo Siou G, Lynch BM, Robson PJ, Friedenreich CM, Csizmadi I. BACKGROUND: Sedentary behaviour has been proposed as a risk factor for obesity that is distinct from physical inactivity. This study aimed to examine the association between occupational sedentary behaviour and obesity, and to determine if this association is independent of leisure-time physical activity (LTPA). METHODS: Fully-employed participants enrolled between 2001 and 2008 to the Tomorrow Project, a prospective cohort study in Alberta, Canada, were studied (n=12,409). Associations between occupational sedentary behaviour and waist circumference (WC), waist-to-hip ratio (WHR), and body mass index (BMI) were examined using multiple binary and multinomial logistic regressions. RESULTS: In men, a positive association was observed between daily occupational sedentary hours and WC, WHR, BMI and with high risk profiles that incorporated both BMI and WC (P<0.01). Controlling for vigorous-intensity LTPA in all models strengthened associations between sedentary behaviour and measures of obesity. In contrast, inverse associations were observed for occupational sedentary hours and WHR for women (P<0.05). CONCLUSIONS: In fully-employed men, occupational sedentary behaviour was positively associated with obesity risk that was not attenuated by physical activity. In women, an increase in obesity risk was not observed with sedentary behaviour. Gender differences in the health effects of sedentary behavior require further study. http://www.ncbi.nlm.nih.gov/pubmed/25830327

Linking Canadian population health data: maximizing the potential of cohort and administrative data

Linking Canadian population health data: maximizing the potential of cohort and administrative data Journal: Can J Public Health| Pages: 258-261 |Date: March 2013 | Authors: Doiron D, Raina P, Fortier I Linkage of data collected by large Canadian cohort studies with provincially managed administrative health databases can offer very interesting avenues for multidisciplinary and cost-effective health research in Canada. Successfully co-analyzing cohort data and administrative health data (AHD) can lead to research results capable of improving the health and well-being of Canadians and enhancing the delivery of health care services. However, such an endeavour will require strong coordination and long-term commitment between all stakeholders involved. The challenges and opportunities of a pan-Canadian cohort-to-AHD data linkage program have been considered by cohort study investigators and data custodians from each Canadian province. Stakeholders acknowledge the important public health benefits of establishing such a program and have established an action plan to move forward. http://www.ncbi.nlm.nih.gov/pubmed/23823892

Prevalence of meeting physical activity guidelines for cancer prevention in Alberta

Prevalence of meeting physical activity guidelines for cancer prevention in Alberta Journal: Chronic Dis Inj Can|Date: September 2012 | Pages: 216-226 | Authors: Aparicio-Ting FE, Friedenreich CM, Kopciuk KA, Plotnikoff RC, Bryant HE. INTRODUCTION: Guidelines for recommended physical activity (PA) levels have been developed by the Canadian Society for Exercise Physiology (CSEP) and the U.S. Department of Health and Human Services (USDHHS) for health benefits and by the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) for cancer prevention benefits. METHODS: We examined if these guidelines were met using a sample of 14 294 Albertan participants of the Tomorrow Project, aged 35 to 64 years, enrolled from 2001 to 2005. We used logistic regression to examine correlates of leisure PA behaviour. RESULTS: An estimated 55%, 42%, 26% and 23% of participants met CSEP, ACS, USDHHS, and WCRF/AICR guidelines, respectively. Women were less likely than men to meet ACS (Odds Ratio [OR] = 0.72, 95% confidence interval [CI]: 0.55-0.93), USDHHS (OR = 0.67, 95% CI: 0.50-0.89) and WCRF/AICR (OR = 0.63, 95% CI: 0.47-0.85) guidelines, and being obese was correlated with not meeting USDHHS (OR = 0.45, 95% CI: 0.32-0.65) and WCRF/AICR guidelines (OR = 0.79, 95% CI: 0.63-0.98). CONCLUSION: Albertans, particularly women and obese individuals, are not sufficiently active for cancer prevention benefits. http://www.ncbi.nlm.nih.gov/pubmed/23046804

The Sedentary Time and Activity Reporting Questionnaire (STAR-Q): Reliability and validation against doubly labelled water and seven-day diaries

The Sedentary Time and Activity Reporting Questionnaire (STAR-Q): reliability and validity against doubly labeled water and 7-day activity diaries. Journal: Am J Epidemiol | Pages: 424-435| Date: August 2014 | Authors: Csizmadi I, Neilson HK, Kopciuk KA, Khandwala F, Liu A, Friedenreich CM, Yasui Y, Rabasa-Lhoret R, Bryant HE, Lau DC, Robson PJ. We determined measurement properties of the Sedentary Time and Activity Reporting Questionnaire (STAR-Q), which was designed to estimate past-month activity energy expenditure (AEE). STAR-Q validity and reliability were assessed in 102 adults in Alberta, Canada (2009-2011), who completed 14-day doubly labeled water (DLW) protocols, 7-day activity diaries on day 15, and the STAR-Q on day 14 and again at 3 and 6 months. Three-month reliability was substantial for total energy expenditure (TEE) and AEE (intraclass correlation coefficients of 0.84 and 0.73, respectively), while 6-month reliability was moderate. STAR-Q-derived TEE and AEE were moderately correlated with DLW estimates (Spearman’s ρs of 0.53 and 0.40, respectively; P < 0.001), and on average, the STAR-Q overestimated TEE and AEE (median differences were 367 kcal/day and 293 kcal/day, respectively). Body mass index-, age-, sex-, and season-adjusted concordance correlation coefficients (CCCs) were 0.24 (95% confidence interval (CI): 0.07, 0.36) and 0.21 (95% CI: 0.11, 0.32) for STAR-Q-derived versus DLW-derived TEE and AEE, respectively. Agreement between the diaries and STAR-Q (metabolic equivalent-hours/day) was strongest for occupational sedentary time (adjusted CCC = 0.76, 95% CI: 0.64, 0.85) and overall strenuous activity (adjusted CCC = 0.64, 95% CI: 0.49, 0.76). The STAR-Q demonstrated substantial validity for estimating occupational sedentary time and strenuous activity and fair validity for ranking individuals by AEE. http://www.ncbi.nlm.nih.gov/pubmed/25038920

Understanding Healthy Eating Behaviour Within the Context of the Modern Food Environment

Understanding Health Eating Behaviour Within the Context of the Modern Food Environment Date: 2013 | Authors: Tarra L Penney The prevention of chronic disease requires understanding and intervention related to both individual and environmental level determinants. However, traditional approaches to chronic disease prevention and management have primarily been focused at the individual level, with limited attention toward environmental level influences on health behaviour. This lack of comprehensiveness is partially due to a paucity of complex theoretical frameworks for clarifying the influences of personal cognitive, and broader environmental, variables on a range of health behaviours. Therefore, the purpose of this research was to expand and test a popular health behaviour theory, Social Cognitive Theory (SCT), to include influences of the perceived food environment on healthy eating behaviour. This study involved two phases. Phase 1 expanded SCT to include a perceived food environment construct through review of the food environment literature. Phase 2 conducted a cross-sectional study of 201 adults (age 35 to 69 years) using an online survey to test the expanded SCT informed by phase 1. Data analysis included descriptive statistics and structural equation modeling (SEM) to compare the traditional and expanded SCT model. Results demonstrated no significant model fit, with no improvement in oveall fit with the inclusion of the perceived food environment. However, the expansion of SCT to include perceived food environment attributes altered the pathways of influence within the social cognitive model, suggesting that the presence of perceived environment measures is important for understanding how perceived environments might mediate the effect of personal cognitive influences on eating behaviour. These findings have implications for food environment research, the development of ecological theories, the field of health promotion and the prevention of chronic disease. http://dalspace.library.dal.ca/handle/10222/35463

Depressive symptoms, diet quality, physical activity, and body composition

Depressive symptoms, diet quality, physical activity, and body composition among populations in Nova Scotia, Canada: report from the Atlantic Partnership for Tomorrow’s Health. Journal: Preventive Medicine | Volume: 61 | Pages:  106-13 | Date: April 2014 | Authors: Zhijie M. Yu, Louise Parker, Trever J.B. Dummer OBJECTIVE: To investigate the association between depressive symptoms and diet quality, physical activity, and body composition among Nova Scotians. METHODS: 4511 men and women aged 35-69 years were recruited to the Atlantic Partnership for Tomorrow’s Health study from 2009 through 2010 in Nova Scotia, Canada. Depressive symptoms were assessed by using the Patient Health Questionnaire. Anthropometric indexes and body composition were measured. Current antidepressant use, habitual diet intake, physical activity, and potential confounders were collected through questionnaires. RESULTS: In multivariable regression analyses, depressive symptoms were positively associated with all obese indexes after controlling for potential confounders (all P for trend<0.001). Compared with non-depressed individuals, those with mild and major depression had significantly increased odds ratios (ORs) for both obesity and abdominal obesity (OR 1.84; 95% confidence interval [CI], (1.50, 2.25) and 1.56 (95% CI, 1.30, 1.87) for obesity and 1.46 (95% CI, 1.20, 1.77) and 1.88 (95% CI, 1.58, 2.24) for abdominal obesity, respectively). Depressed individuals were less likely to have a high quality diet or engage in high levels of physical activity compared with their non-depressed counterparts. CONCLUSIONS: Depressive symptoms are associated with higher levels of obesity, poor diet, and physical inactivity among Nova Scotians in Canada.

Geostatistical modelling of arsenic

Geostatistical modelling of arsenic in drinking water wells and related toenail arsenic concentrations across Nova Scotia, Canada Journal: Science of The Total Environment | Volume: 505 | Pages: 1248-58 | Date: February 1 2015 | Authors: T.J.B. Dummer, Z.M. Yu, L. Nauta, J.D. Murimboh, L. Parker Arsenic is a naturally occurring class 1 human carcinogen that is widespread in private drinking water wells throughout the province of Nova Scotia in Canada. In this paper we explore the spatial variation in toenail arsenic concentrations (arsenic body burden) in Nova Scotia. We describe the regional distribution of arsenic concentrations in private well water supplies in the province, and evaluate the geological and environmental features associated with higher levels of arsenic in well water. We develop geostatistical process models to predict high toenail arsenic concentrations and high well water arsenic concentrations, which have utility for studies where no direct measurements of arsenic body burden or arsenic exposure are available. 892 men and women who participated in the Atlantic Partnership for Tomorrow’s Health Project provided both drinking water and toenail clipping samples. Information on socio-demographic, lifestyle and health factors was obtained with a set of standardized questionnaires. Anthropometric indices and arsenic concentrations in drinking water and toenails were measured. In addition, data on arsenic concentrations in 10,498 private wells were provided by the Nova Scotia Department of Environment. We utilised stepwise multivariable logistic regression modelling to develop separate statistical models to: a) predict high toenail arsenic concentrations (defined as toenail arsenic levels ≥0.12μgg(-1)) and b) predict high well water arsenic concentrations (defined as well water arsenic levels ≥5.0μgL(-1)). We found that the geological and environmental information that predicted well water arsenic concentrations can also be used to accurately predict toenail arsenic concentrations. We conclude that geological and environmental factors contributing to arsenic contamination in well water are the major contributing influences on arsenic body burden among Nova Scotia residents. Further studies are warranted to assess appropriate intervention strategies for reducing arsenic body burden among human populations.

Relationship between drinking water and toenail arsenic concentrations among a cohort of Nova Scotians

Authors: Zhijie M Yu, Trevor J.B. Dummer, Aimee Adams, John D Murimboh and Louise Parker Journal: Journal of Exposure Science and Environmental Epidemiology | Volume: 24 | Pages: 135-44 |Date: 2014 | Abstract: Consumption of arsenic-contaminated drinking water is associated with increased cancer risk. The relationship between arsenic body burden, such as concentrations in human toenails, and arsenic in drinking water is not fully understood. We evaluated the relationship between arsenic concentrations in drinking water and toenail clippings among a cohort of Nova Scotians. A total of 960 men and women aged 35 to 69 years provided home drinking water and toenail clipping samples. Information on water source and treatment use and covariables was collected through questionnaires. Arsenic concentrations in drinking water and toenail clippings and anthropometric indices were measured. Private drilled water wells had higher arsenic concentrations compared with other dug wells and municipal drinking water sources (P<0.001). Among participants with drinking water arsenic levels ≥1 μg/l, there was a significant relationship between drinking water and toenail arsenic concentrations (r=0.46, P<0.0001). Given similar levels of arsenic exposure from drinking water, obese individuals had significantly lower concentrations of arsenic in toenails compared with those with a normal weight. Private drilled water wells were an important source of arsenic exposure in the study population. Body weight modifies the relationship between drinking water arsenic exposure and toenail arsenic concentrations.   https://www.nature.com/jes/journal/v24/n2/pdf/jes201388a.pdf

Atlantic PATH earns Guinness World Record for world’s largest toenail collection

Atlantic PATH earns Guinness World Record for world’s largest toenail collection  (Originally Published at Dalhousie University) The record may seem silly, but the science behind it is incredibly important to understanding why Atlantic Canada has such high rates of cancer. The Atlantic Partnership for Tomorrow’s Health, or “PATH,” is part of the Canadian Partnership for Tomorrow Project, the largest study of its kind ever undertaken in Canada. Led by a group of Dal researchers, Atlantic PATH is investigating the various factors that contribute to the development of cancer and chronic diseases: everything from the environment, to genetics, to lifestyle and behaviour. It’s recruiting tens of thousands men and women, ages 35-69, from across the four Atlantic provinces to take part. So far, more than 30,000 individuals have participated in the study, providing the Atlantic PATH team with body measurements, blood samples and…toenail clippings? “Toenails are an important part of our research,” explains Atlantic PATH’s Principal Investigator Dr. Louise Parker, professor in the Departments of Pediatrics and Medicine as well as the Canadian Cancer Society Chair in Population Cancer Research. “By the time you trim the end of your toenails, they’ve been on your body for about six-to-nine months and during that time they’re exposed to everything that you’re exposed to. What we’re particularly interested in, in this context, is the extent to which environmental exposure affects our risk of disease.” A record collection Dr. Parker and her team had no idea their quest to better understand cancer in Atlantic Canada would lead to a Guinness World Record but, sure enough, collecting toenails from 24,999 individuals was enough to earn Atlantic PATH the honour of owning the world’s largest collection of toenail clippings. “My colleagues David Thompson and Trevor Dummer had the idea,” says Dr. Parker, when asked about how they decided to submit the collection to the Guinness organization. “It’s a heck of a collection: a quarter of a million toenail clippings altogether. So they looked at the Guinness website and while there were other toenail records — for example, the longest toenails — there wasn’t a record for the largest collection of clippings. We thought it was a great opportunity to have a bit of fun after everyone’s hard work and commitment to the project.” So what sort of insights are the Atlantic PATH team finding in its impressive toenail collection? One of the first things being studied in the clippings is arsenic levels. “It’s a known carcinogen and increases the rates of several cancers, including that of the bladder and kidney,” says Dr. Parker. “Arsenic is a natural contaminant of many water supply wells in Nova Scotia, and we want to find out if drinking arsenic-contaminated water is one of the reasons rates of bladder and kidney cancer are higher in Atlantic Canada than most of the rest of Canada.” What the team has found is that body fat plays a role in how arsenic is absorbed into the body. In particular, women with higher levels of fat are less likely to retain arsenic in their body. An important project Atlantic PATH’s research into the factors that lead to cancer and other diseases is particularly important for our region, which has the highest rates of cancer in the country. One in three Atlantic Canadians will develop cancer in their lifetime. Each year, more than 13,400 Atlantic Canadians are diagnosed with cancer, and 6,300 die from the disease. This is the last year for recruiting participants to Atlantic PATH, and the study is not only still welcoming new participants, but are encouraging individuals who have donated their toenails to make sure they visit a clinic for a full blood sample test if they haven’t yet. “It’s an opportunity to contribute to incredibly important research,” says Dr. Parker