New Article – The Association of Sleep Trouble and Physical Inactivity with Breast Cancer Risk in Nova Scotia

Congratulations to Dr. Cindy Feng on her new article, “The Association of Sleep Trouble and Physical Inactivity with Breast Cancer Risk in Nova Scotia: Evidence from the Atlantic PATH Cohort.” Breast cancer is a major public health concern, and modifiable health behaviors such as sleep quality and physical activity may influence risk. This study examined the associations between self-reported sleep trouble, sleep duration, and physical activity with breast cancer incidence in a prospective longitudinal cohort of 10,305 females from Nova Scotia. This work is part of Dr. Feng’s ongoing research with Atlantic PATH focused on predictive modeling and geographical analysis of cancer incidence in Atlantic Canada.  

National Health and Fitness Day

June 1st was National Health and Fitness Day! ? It is important to recognize the importance of maintaining the health of our communities and the vital role of regular physical activity among Canadians. CanPath and our regional cohorts strive to advance research that promotes healthy living and well-being for everyone. Check out these interesting findings based on research conducted with Atlantic PATH cohort data, focusing primarily on the relationship between multimorbidity and physical activity. Together, we can build a healthier, more active, and fit future! ?

Dr. Jennifer Vena and Dr. Rachel Murphy at #CCRC2023

Dr. Jennifer Vena and Dr. Rachel Murphy will be attending the Canadian Cancer Research Conference from Alberta and British Columbia. Dr. Vena is the Scientific Director of Alberta’s Tomorrow Project and a Research Scientist at CancerControl Alberta with Alberta Health Services. Dr. Vena’s research interests focus on lifestyle behaviours and prevention of cancer and chronic diseases, as well as population cohort science, and involves scientific, strategic, and operational elements. Dr. Vena will be presenting a poster on the dietary screener that was developed to assess adherence to Canada’s Food Guide and how it could be used for cancer prevention research. Posters will be up for the duration of the conference and during viewing sessions on Sunday, November 12th from 12-1:30pm AST and Monday, November 13th from 1:10-2:40pm AST.  Dr. Murphy is a Senior Scientist at BC Cancer and an Associate Professor at the School of Population and Public Health at the University of British Columbia. Dr. Murphy’s research interests include reducing the risk of cancer through modifiable lifestyle factors, with a focus on healthy eating and body weight. Additional interests include older adults and other populations with increased risk of cancer, knowledge translation of nutrition evidence, and metabolomics; the study of small molecules in biological systems that may provide insight on pathways linking lifestyle factors and disease.   Dr. Murphy will be presenting at and chairing a session with Patient Partner, Rachelle Bould on Reducing Your Risk of Cancer on Tuesday, November 14th at 9:00am AST. The presenters include:  Dr. Rachel Murphy (University of British Columbia, BC Cancer) speaking about diet, geographies and risk for cancer  Dr. Laura Struik (University of British Columbia) speaking about factors influencing youth vaping uptake  Dr. Paul Demers (Occupational Cancer Research Centre, Ontario Health) speaking about the etiology of rare cancers in a large occupational cohort  Umaima Abbas (University of Western Ontario) speaking about the effectiveness and cost-effectiveness of population level policies to reduce alcohol use   

Langille and PAC (Keats/Grandy) Labs at #CCRC2023

The Langille and PAC (Keats/Grandy) labs will be well represented at the Canadian Conference for Cancer Research. Dr. Morgan Langille is the Canada Research Chair in Human Microbiomics and an associate professor in the Departments of Pharmacology, and Microbiology and Immunology at Dalhousie University. He leads the Langille Lab which strives to better understand the role of the microbiome in various diseases by developing and testing novel bioinformatic methods. Dr. Robyn Wright is a postdoctoral research fellow in the Langille Lab who is interested in microbial ecology/microbial community dynamics in natural and synthetic systems and how these respond to change, as well as mitigating anthropogenic impacts on the environment. Dr. Wright will be presenting in a concurrent session on linking tumour, blood and oral microbiomes with cancer outcomes on Monday, November 13th at 4:40pm. The session on the Gut Microbiome for Precision Oncology will be chaired by Dr. Bertrand Routy (CHUM/CRCHUM) and Patient Partner, Darren Frew.  Dr. Vanessa DeClercq will also be in attendance at the conference. Dr. DeClercq is a Research Associate in the Langille Lab and holds an Adjunct appointment in Department of Community Health & Epidemiology at Dalhousie University. Dr. DeClercq is an Associated Researcher and former Research Scientist with Atlantic PATH. Her research interests include the role that lifestyle behaviour, such as diet and activity, play in chronic disease prevention and management.  ***** The Physical Activity for Persons Living with or Affected by Cancer (PAC Lab) will be well represented at the upcoming Canadian Cancer Research Conference. The PAC Lab is directed by Atlantic PATH’s colleagues, Dr. Melanie Keats and Dr. Scott Grandy.  Dr. Melanie Keats is a Professor in the School of Health and Human Performance, Division of Kinesiology, Dalhousie University. She holds a research appointment with the Division of Medical Oncology with Nova Scotia Health, Co-Chairs the Physical Activity and Cancer Care Standards Working Group with the Nova Scotia Cancer Care Program, and is a Senior Research Scientist with the Beatrice Hunter Cancer Research Institute. Dr. Keats’ research takes an interdisciplinary approach to better understanding the role of exercise in improving the quality of life of cancer survivors.        Dr. Scott Grandy is an Associate Professor in the School of Health and Human Performance, Division of Kinesiology, Dalhousie University. He holds a research appointment with the Division of Medical Oncology with Nova Scotia Health and is a Senior Research Scientist with the Beatrice Hunter Cancer Research Institute. Dr. Grandy’s research interests include kinesiology, and cardiovascular disease and exercise, disease prevention, and aging.     Tom Christensen, MSc is the Research Coordinator and Senior Clinical Physiologist in the PAC Lab. Tom will present a poster on missed opportunities in supporting informal cancer caregiver (and patient) health. Posters will be up for the duration of the conference and during viewing sessions on Sunday, November 12th from 12-1:30pm AST and Monday, November 13th from 1:10-2:40pm AST.  Tom will also present this work in the lightning session in a panel on Cancer Survivorship on Sunday, November 12th at 1:30pm AST.      Jodi Langley, Msc is a doctoral candidate in the School of Health and Human Performance at Dalhousie University. Jodi will present a poster on the associations among referral source, enrollment, and adherence to an exercise oncology program for individuals in rural and remote communities in the EXCEL study. Posters will be up for the duration of the conference and during viewing sessions on Sunday, November 12th from 12-1:30pm AST and Monday, November 13th from 1:10-2:40pm AST.    Steph Kendall, MSc, completed her Master’s research with supervisor, Dr. Grandy. A poster  will be presented focused on altered lipid-based metabolites as early markers of anthracycline-induced cardiotoxicity and the cardioprotective benefits of physical activity in breast cancer patients. Posters will be up for the duration of the conference and during viewing sessions on Sunday, November 12th from 12-1:30pm AST and Monday, November 13th from 1:10-2:40pm AST.    Dr. Stefan Heinze is a postdoctoral fellow with the PAC Lab and the Nova Scotia Health Authority’s Cancer Care Program working towards integrating exercise and physical activity programming as a standard of care. In addition, he has helped to introduce the measurement of frailty into the PAC Lab’s research. He is interested in how we can use frailty assessments to help decide upon the best care pathways for each person living with a cancer diagnosis.  Dr. Heinze will present a poster on activating cancer communities through an exercise strategy for survivors (ACCESS), an implementation-effectiveness study of a 12-week multimodal exercise program for people living with cancer. Posters will be up for the duration of the conference and during viewing sessions on Sunday, November 12th from 12-1:30pm AST and Monday, November 13th from 1:10-2:40pm AST.    *Photo Credit: Dalhousie University

World Mental Health Day

October 10th is World Mental Health Day and Atlantic PATH is pleased to be involved in multiple studies examining mental health and well-being. COVID Global Mental Health Consortium The COVID Global Mental Health Consortium was recently funded and includes 23 global cohorts representing 2.8 million participants. It will produce a global evaluation of pandemic-related mental health outcomes using individual-level harmonized longitudinal data. Research will begin this fall and we look forward to participating and contributing to this important work. Depression, Anxiety and Risk of Cancer Depression and anxiety have long been thought to be related to an increased cancer risk. The Psychosocial Factors and Cancer Incidence (PSY-CA) consortium is led from the Netherlands and includes Atlantic PATH, CARTaGENE (Quebec) and the Ontario Health Study. This study found that mental health was not related to an increased risk of cancer. Shift Work & Mental Health The relationship between mental health and shift work was evaluated among Atlantic PATH participants. Shift workers reported higher levels of each of the mental health domains compared to non-shift workers. Shift workers were more likely to have increased rates of depression and poor self-rated health, as well as depressive and anxiety symptom scores compared to non-shift workers. As a result, shift workers may be at increased risk of comorbidity, poor quality of life, missed work, and early retirement. Physical Activity and Self-Rated Health The population of Atlantic Canada is aging rapidly and has among the highest rates of chronic disease in the country. This study examined the association between physical activity and self-rated health among Atlantic PATH participants. The results suggest that physical activity is associated with and may help to improve perceived health status of individuals with one or more chronic conditions. The findings support literature suggesting that physical activity can be beneficial for adults as they age with chronic disease. Anxiety, Depression and Prostate Cancer Prostate cancer is the most prevalent form of cancer among males in Canada, and has one of the most favorable survival rates among all cancers. The incidence rates are expected to remain high with an aging population and an increase in asymptomatic detection. Prostate cancer survivors had higher odds of anxiety or depression symptoms compared to those with no history of cancer or a history of any other type of cancer. Prostate cancer survivors with a low household income had a higher rate of depression compared to those  with a history of another type of cancer and a high household income. Prostate cancer survivors who were treated with surgery had a higher odds of depression symptoms compared to those with a history of other types of cancer. Increased rates of anxiety and depression among males with a history of prostate cancer highlights the need for mental health screening among prostate cancer survivors. The findings highlight the importance of a multidisciplinary effort to prioritize and deliver comprehensive mental health support throughout the prostate cancer journey.