Author: pathwp

Implementation Science Workshop

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Join the Ontario Institute for Cancer Research for an upcoming Implementation Science Workshop webinar on May 2, 2024 at 1pmEST/2pmAST with guest speaker, Atlantic PATH Scientific Director, Dr. Robin Urquhart. This educational session for the Ontario translational research community is an opportunity to learn more about what implementation science is, how it can be applied to advance the adoption and integration of research into practice, and the appropriate methodology for conducting implementation science. Registration: https://oicr.on.ca/events/implementation-science-workshop/

CanPath Newsletter

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The latest CanPath newsletter highlights new research on mental health service use and COVID-19, rural communities facing higher risks of lung cancer from radon, Colorectal Cancer Awareness Month, and updates from all the regional cohorts. The Atlantic PATH team continues to work remotely to support access requests for researchers for baseline, follow-up and COVID-19 questionnaire datasets. Congratulations to Dr. Maartje Basten and team on the latest PSYchosocial factors and Cancer (PSY-CA) study publication. Led from the Netherlands, this article examines psychosocial factors, health behaviours and risk of cancer incidence. The latest publications from Atlantic PATH can be found here, and the latest news and announcements can be found by following on Twitter, Facebook, LinkedIn, or the website.

CanPath Featured as one of Canada’s Most Successful Investments in Biobanking

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CanPath was featured as one of Canada’s most successful investments in biobanking! ?? In an Open Access Government article, Francois Lamontagne, Paul Hebert, and Michelle Kho (Sepsis Canada) emphasize the critical role of biobanks in generating new insights into healthcare and disease management. They underscore the pitfalls of ‘classic’ biobanks, highlight the low-cost opportunity of ‘living’ biobank infrastructure, and suggest a way forward toward sustainable, high-impact, decentralized, federated, and ‘living’ biobank infrastructure. ?? From understanding genetic influences to environmental factors, Canadians’ biological samples collected through CanPath and regional cohorts’ studies are paving the path for a healthier future. ?? Read the full article here: https://lnkd.in/dN5VdX8j

New Article on Progress in Site-Specific Cancer Mortality

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A new article has been published in Scientific Reports on the progress in site-specific cancer mortality in Canada over the last 70 years. Using data from Statistics Canada and the Global Cancer Observatory, Warkentin et al. (2024) found that there has been “a significant reduction in cancer mortality in Canada since site-specific cancer mortality rates peaked decades ago for many cancers. This shows the exceptional progress made in cancer control in Canada due to substantial improvements in prevention, screening, and treatment.” Link: https://www.nature.com/articles/s41598-024-56150-x  

CanPath Access Office Hours

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Join CanPath for an informative session on accessing CanPath data and biosamples for your research projects! Whether you’re a seasoned researcher or new to the process, our Access Office experts are here to provide insider tips on ensuring your application is successful. The “Access Office Hours” virtual series provides researchers with an opportunity every quarter to ask questions they may have about CanPath data and biosamples, the access process or the CanPath Portal. Members of the Access Office will be available to answer questions and demonstrate how to navigate the Portal and online application. Additional details and registration: https://canpath.ca/2024/03/access-office-hours-insider-tips-for-effective-health-data-applications/

Upcoming CanPath Webinar on Ultra-processed food consumption, depression, and diabetes

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Type 2 diabetes (T2D) is a widespread chronic condition with severe consequences, including complications affecting blood vessels and organs, disability, and premature death. Research indicates that depression can significantly raise the risk of developing T2D, potentially through lifestyle and biological factors. Additionally, our modern diet presents a challenge with the increasing consumption of ultra-processed foods (UPF), which have been linked to a higher risk of obesity, diabetes, and hypertension. In this webinar, Dr. Norbert Schmitz and Dr. Akankasha Sen will share the synergistic effects of depression and UPF consumption on T2D risk and the risk of developing diabetes-specific complications for those with type 2 diabetes. Using longitudinal data from the CARTaGENE cohort, Dr. Schmitz and colleagues demonstrate whether the combination of these factors exacerbates the likelihood of developing T2D beyond their individual effects and whether other mechanisms affect the association, like smoking, alcohol consumption, and physical activity. Additional Details and Registration: https://canpath.ca/2024/03/webinar-ultra-processed-food-consumption-depression-diabetes/

Rural communities face higher risk of lung cancer from radon

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Research conducted using CanPath data, including Atlantic PATH found that at least one in five lung cancer cases diagnosed are found in people who have never smoked. Our colleague, Dr. Aaron Goodarzi has written a new article on the risks of lung cancer that rural communities face as a result of exposure to radon. Full article: https://troymedia.com/health/cancer-risk-from-radon-gas-is-higher-in-rural-communities/

New Publication – Psychosocial factors, health behaviors and risk of cancer incidence

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We are pleased to share that a new publication from the Psychosocial Factors and Cancer Incidence (PSY-CA) consortium have been published in Cancer Epidemiology. Led from the Netherlands by Dr. Lonneke van Tuijl and Dr. Joost Dekker, this study includes 18 cohorts with more than 300,000 participants including Atlantic PATH, the Ontario Health Study and CARTaGENE from CanPath. Our local team members include Mr. Yunsong Cui (Atlantic PATH) who completed all local analyses, Dr. Ellen Sweeney (Atlantic PATH) and Dr. Melanie Keats (Dalhousie University). Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress. Link to article: http://doi.org/10.1002/ijc.34852

Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

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Authors: Maartje Basten, Kuan-Yu Pan, Lonneke A. vanTuijl, Alexander deGraeff, Joost Dekker, Adriaan W.Hoogendoorn, Femke Lamers, Adelita V. Ranchor, Roel Vermeulen, Lützen Portengen, Adri C. Voogd, Jessica Abell, Philip Awadalla, Aartjan T.F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn Huisman, Anke Huss, Melanie R. Keats, Almar A.L. Kok, Steinar Krokstad, Flora E. vanLeeuwen, Annemarie I. Luik, NolwennNoisel, Yves Payette, Brenda W.J.H. Penninx, Ina Rissanen, Annelieke M. Roest, Judith G.M. Rosmalen, Rikje Ruiter, Robert A. Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Emma L. Twait, Alison Teyhan, W.M. Monique Verschuren, Kimberly D. vanderWillik, Mirjam I. Geerlings Journal: International Journal of Cancer Abstract: Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects o fhealth behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two-stage individual participant data meta-analyses were performed based on 22cohorts of the PSYchosocial factors and CAncer (PSY-CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, anxiety diagnosis, anxiety symptoms, perceived social support, loss events, general distress, neuroticism, relationship status), seven health behaviors/behavior-related factors (smoking, alcohol use, physical activity, body mass index, sedentary behavior, sleep quality, sleep duration)and seven cancer outcomes (overall cancer, smoking-related, alcohol-related, breast, lung, prostate, colorectal). Effects of the psychosocial factor, health behavior and their product term on cancer incidence were estimated using Cox regression. We pooled cohort-specific estimates using multivariate random-effects meta-analyses. Additive and multiplicative interaction/effect modification was examined. This study involved 437,827 participants, 36,961 incident cancer diagnoses, and 4,749,481 person years of follow-up. Out of 744 combinations of psychosocial factors, health behaviors, and cancer outcomes, we found no evidence of interaction. Effect modification was found for some combinations, but there were no clear patterns for any particular factors or outcomes involved. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress. doi: 10.1002/ijc.34852