Congratulations to Drs. Syed Sibte Raza Abidi, Jong Sung Kim, Ellen Sweeney, Gabriela Ilie, and Trevor Dummer on a successful New Frontiers in Research Fund’s Exploration grant.

The highly competitive funding is meant to support high-risk, high-reward and interdisciplinary research. The NFRF funding is “especially meaningful because it encourages our scholars to push the boundaries of knowledge. This is how great discoveries are made,” says Alice Aiken, Vice-President, Research and Innovation. “It’s exciting to see our researchers harnessing machine learning, natural language processing and other cutting-edge techniques to reveal new truths that can improve our health and society.” (Source: DalNews, https://bit.ly/3O8Agi7). Using Atlantic PATH data and toenail samples, this funding will allow the research team to expand on their work on arsenic-related cancer and machine learning. Based on Canada’s geology, arsenic represents one of the most prevalent environmental carcinogens linked to skin, bladder, kidney, prostate, lung, breast, and cervical cancer. Half of Canadians are susceptible to develop cancer in their lifetime, with risk modified heavily by genetic susceptibility, behavioural factors and environmental exposure. While cancer risk prevention strategies have extensively focused on physiological and behavioural factors, environmental exposure as a cancer risk has not been well studied which has led to missed opportunities to reduce the risk of cancer through environmental population health programs, such as reducing chronic arsenic exposure by treating contaminated groundwater currently consumed by Canadians. Increased arsenic levels in human toenails have been detected in the Atlantic PATH cohort. Innovative population health interventions, focusing on predicting the susceptibility and type of arsenic induced cancer across Canada are urgently needed to mitigate the increasing prevalence of cancers in Canada. This work will investigate environmental cancer biomarkers and develop innovative data-driven environmental cancer risk assessment tools to help reduce the incidence of cancers caused by arsenic exposure. Please stay tuned for updates from this project!

Participant Town Hall

Did you miss CanPath’s Participant Town Hall? It can be viewed on CanPath’s YouTube channel. Learn about how participant data and biosamples are being used in cancer, COVID-19 and chronic disease research. English: https://www.youtube.com/watch?v=UbBFTVwKOzE French: https://www.youtube.com/watch?v=Yj7tfI_ay04

New Publication! Toenail speciation biomarkers in arsenic‐related disease: a feasibility study for investigating the association between arsenic exposure and chronic disease

Congratulations to Nathan Smith & colleagues!! Based on his MSc research, this is important foundational work examining toenails as biomarkers for arsenic speciation that Atlantic PATH and the HERC Lab continue to build on. https://bit.ly/332UU0r

CanPath to Study the Impact and Immune Response to COVID-19 Infection and Vaccination

The Government of Canada is investing $1.9m through the COVID-19 Immunity Task Force (CITF) to fund an extension of CanPath’s COVID-19 Antibody Study over a longer period of time, allowing for additional collection of blood samples and questionnaires. The CanPath COVID-19 Antibody Study is implemented in collaboration with CanPath’s regional cohorts, including Atlantic PATH, CARTaGENE (Quebec), the Ontario Health Study, the Manitoba Tomorrow Project, Alberta’s Tomorrow Project, and the BC Generations Project. CanPath is a national population health research platform that follows the health of 330,000 volunteer Canadians (or approximately 1% of the population). Its pan-Canadian COVID-19 Antibody Study will now collect a second dried blood spot sample from over 20,000 Canadians, aged 30 and older. Researchers will test the samples for presence and level of antibodies to SARS-CoV-2, produced in response to either vaccination or past infection with the novel coronavirus. Please click here for additional details: https://bit.ly/3I6lWE5

New Publication: Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

We are pleased to share that the protocol for the PSY-CA consortium on psychosocial factors and cancer incidence has been published. Led from the Netherlands by Dr. Lonneke van Tuijl and Dr. Joost Dekker, this study includes 18 cohorts including Atlantic PATH, the Ontario Health Study and CARTaGENE from CanPath. https://bit.ly/38B8oQc

New Pulication: Post-Treatment Adverse Health Correlates among Prostate Cancer Survivors in a Sample of Men Residing in Atlantic Canada

Congratulations to Dr. Gabriela Ilie, Dr. Rob Rutledge and Dr. Ellen Sweeney on their publication in Current Oncology! This is the third article in a series of research on prostate cancer survivors in Atlantic PATH funded by Beatrice Hunter Cancer Research Institute. It examines the post-treatment adverse health correlates among prostate cancer survivors in Atlantic PATH. https://bit.ly/3x0hqAd

New Publication: Environmental Correlates of Physical Activity, Sedentary Behavior, and Self-Rated Health in Chronic Obstructive Pulmonary Disease

Congratulations to Dr. Daniel Stevens, Dr. Pantelis Andreou and Dr. Daniel Rainham on their publication on environmental correlates of physical activity, sedentary behaviour and self-rated health in chronic obstructive pulmonary disease (COPD) in the Journal of Cardiopulmonary Rehabilitation and Prevention. https://bit.ly/2Vi6FvO

New Publication: Age and Sex-Specific Associations in Health Risk Factors for Chronic Disease

We’re happy to share a new article from Dr. Vanessa DeClercq & Dr. Ellen Sweeney on the age- & sex-specific associations in health risk factors for chronic disease in the Atlantic PATH cohort. They found that there are evident differences in health risk factors for males and for females, as well as across age groups, and public health efforts need to account for the role played by sex and age in addressing chronic disease burden in Canadian adults. https://bit.ly/36UxHMx

Shift Work and Mental Health: Findings from a new Atlantic PATH study

We are pleased to announce the latest in our research on Atlantic PATH shift workers! Sweeney et al. (2021) evaluated the relationship between mental health and shift work in a matched study with 12,413 participants, including 4155 shift workers and 8258 non-shift workers. Shift workers were more likely to have increased rates of depression and poor self-rated health, as well as depressive and anxiety symptom scores compared to non-shift workers. The full article can be found free for 50 days compliments of Elsevier – https://authors.elsevier.com/a/1dMIjKt2p%7EjIi This research builds on our previous work that found an increased risk of cardiovascular disease, obesity and diabetes among shift workers, despite higher levels of physical activity and lower levels of sedentary behaviour (https://bit.ly/2TJEoxN).    

Early results from CanPath’s national study confirm antibody levels are stronger after receiving two doses of COVID-19 vaccine

Initial preliminary results from the Canadian Partnership for Tomorrow’s Health (CanPath) COVID-19 Antibody Study, based on close to 6,000 dried blood spot samples collected between February 8 and May 17, 2021, show a high degree of variability in the level of antibodies produced by a single dose of a COVID-19 vaccine. These findings highlight the importance of accelerating second doses as the Delta variant continues to spread, particularly with the vast majority of Canadians having received only a single vaccine dose. This is the first pan-Canadian study using samples from a wide range of participants to confirm evidence from vaccine manufacturers’ clinical trials, as well as findings in a recent preprint from the United Kingdom and other smaller studies.   Participants from Atlantic PATH, CARTaGENE, the Ontario Health Study, Manitoba Tomorrow Project, Alberta’s Tomorrow Project, and BC Generations contributed to the COVID-19 Antibody Study. https://bit.ly/3gVLeb2