Prostate Cancer Awareness Month

This #ProstateCancerAwarenessMonth, we’re sharing insights from recent studies from researchers across Canada. Today, we’re sharing findings from Sheida Majouni, PhD candidate from Dalhousie University! In 2022, Majouni and colleagues applied machine learning to arsenic species and metal profiles of toenails from Atlantic PATH. They aimed to understand environmental metal’s potential to produce disease, specifically prostate cancer: https://bit.ly/3eVjUMK “Artificial intelligence has a unique potential to revolutionize population health,” says Dr. Syed Sibte Raza Abidi, Professor in the Faculty of Computer Science at Dalhousie University. “By discovering environmental risk factors’ influence on chronic disease risk with risk prediction models, it is a pivotal tool for mitigating the risk of chronic disease onset.” This work is being expanded with the support of a New Frontiers in Research Fund (NFRF) Exploration grant. Team members include Dr. Syed Sibte Raza Abidi (Nominated Principal Investigator), Dr. Jong Sung Kim (Co-Principal Investigator), Dr. Ellen Sweeney (Co-Investigator), Dr. Gabriela Ilie (Co-Investigator), Dr. Trevor Dummer (Co-Investigator), Dr. Taehyun Roh (Collaborator), Dr. Nathalie Saint-Jacques (Collaborator), and Jason Hicks (Collaborator). Watch this space for future findings!

New Publication

Congratulations to Majouni et al. on the new publication, “Applying Machine Learning to Arsenic Species and Metallomics Profiles of Toenails to Evaluate Associations of Environmental Arsenic with Incident Cancer Cases.” This research involves analyzing toenail samples from Atlantic PATH, as well as machine learning algorithms to arsenic species and metallomics profiles to investigate the complex association between environmental arsenic as a carcinogen and prostate cancer. https://ebooks.iospress.nl/doi/10.3233/SHTI220385  

Funding News

Congratulations to Dr. Samina Abidi, Dr. Raza Abidi, Dr. Ellen Sweeney and team on their successful CIHR Catalyst grant, “Digital Health and Artificial Intelligence based Platform for Early Chronic Disease Risk Assessment and Prediction to Improve Population Health.”  This project will leverage digital health/e-health and artificial intelligence technologies to develop a Personalized Risk Investigation, Stratification and Mitigation (PRISM) platform to assess chronic disease risk. “

Five Years of Team PATH and Plaid for Dad

The Atlantic PATH team is always happy to support the Canadian Cancer Society’s Plaid for Dad event which raises awareness about prostate cancer and supports prostate cancer research in Canada. There were two years when we could be together for Plaid for Dad in the office and with our office dog Flash. We’re happy to be able to continue participating while we work from home during COVID-19 the past few years, safely social distancing! You can read more about the Plaid for Dad campaign here: https://bit.ly/3QrMbZC                            

Congratulations to Dr. Robin Urquhart and the CanPath team across the country!

Funded by the Canadian Cancer Society Data Transformation Grant, this work will connect cancer registry and administrative health data with CanPath data creating a unified resource for cancer research in Canada. https://bit.ly/3OojlZ2 Urquhart R, Awadalla P, Bhatti P, Dummer T, Gravel S, Vena J, Alvi R, Broet P, Kendell C, Kirsh V, Lettre G, Skead K, Sweeney E, Turner D. Harnessing the power of linked data to understand cancer and its outcomes: a national linkage project. March 2022-March 2023, CCS Data Transformation Grant. Canada has a wealth of health care and health research data, but numerous barriers prevent efficient sharing of these datasets between provinces. This, combined with further difficulties with linking datasets together, causes major limitations in using the data productively to improve the health of Canadians. With support from the Canadian Cancer Society, Dr Urquhart will lead a team to connect several cancer registry and administrative health data repositories, creating a unified resource for cancer research in Canada. One of the datasets, CanPath, contains data on 1 in 100 Canadians, including lifestyle, family histories, genetics and environment and this, combined with other datasets, will be analysed to understand the causes of cancer and what happens to people with cancer in the short- and long-term. The researchers will also be able to ask important questions about the impact of the COVID-19 pandemic on people who have been diagnosed with cancer during this time. Linking these huge datasets will provide a very important resource for cancer research in Canada.

Congratulations to Drs. Syed Sibte Raza Abidi, Jong Sung Kim, Ellen Sweeney, Gabriela Ilie, and Trevor Dummer on a successful New Frontiers in Research Fund’s Exploration grant.

The highly competitive funding is meant to support high-risk, high-reward and interdisciplinary research. The NFRF funding is “especially meaningful because it encourages our scholars to push the boundaries of knowledge. This is how great discoveries are made,” says Alice Aiken, Vice-President, Research and Innovation. “It’s exciting to see our researchers harnessing machine learning, natural language processing and other cutting-edge techniques to reveal new truths that can improve our health and society.” (Source: DalNews, https://bit.ly/3O8Agi7). Using Atlantic PATH data and toenail samples, this funding will allow the research team to expand on their work on arsenic-related cancer and machine learning. Based on Canada’s geology, arsenic represents one of the most prevalent environmental carcinogens linked to skin, bladder, kidney, prostate, lung, breast, and cervical cancer. Half of Canadians are susceptible to develop cancer in their lifetime, with risk modified heavily by genetic susceptibility, behavioural factors and environmental exposure. While cancer risk prevention strategies have extensively focused on physiological and behavioural factors, environmental exposure as a cancer risk has not been well studied which has led to missed opportunities to reduce the risk of cancer through environmental population health programs, such as reducing chronic arsenic exposure by treating contaminated groundwater currently consumed by Canadians. Increased arsenic levels in human toenails have been detected in the Atlantic PATH cohort. Innovative population health interventions, focusing on predicting the susceptibility and type of arsenic induced cancer across Canada are urgently needed to mitigate the increasing prevalence of cancers in Canada. This work will investigate environmental cancer biomarkers and develop innovative data-driven environmental cancer risk assessment tools to help reduce the incidence of cancers caused by arsenic exposure. Please stay tuned for updates from this project!

Participant Town Hall

Did you miss CanPath’s Participant Town Hall? It can be viewed on CanPath’s YouTube channel. Learn about how participant data and biosamples are being used in cancer, COVID-19 and chronic disease research. English: https://www.youtube.com/watch?v=UbBFTVwKOzE French: https://www.youtube.com/watch?v=Yj7tfI_ay04

New Publication! Toenail speciation biomarkers in arsenic‐related disease: a feasibility study for investigating the association between arsenic exposure and chronic disease

Congratulations to Nathan Smith & colleagues!! Based on his MSc research, this is important foundational work examining toenails as biomarkers for arsenic speciation that Atlantic PATH and the HERC Lab continue to build on. https://bit.ly/332UU0r

CanPath to Study the Impact and Immune Response to COVID-19 Infection and Vaccination

The Government of Canada is investing $1.9m through the COVID-19 Immunity Task Force (CITF) to fund an extension of CanPath’s COVID-19 Antibody Study over a longer period of time, allowing for additional collection of blood samples and questionnaires. The CanPath COVID-19 Antibody Study is implemented in collaboration with CanPath’s regional cohorts, including Atlantic PATH, CARTaGENE (Quebec), the Ontario Health Study, the Manitoba Tomorrow Project, Alberta’s Tomorrow Project, and the BC Generations Project. CanPath is a national population health research platform that follows the health of 330,000 volunteer Canadians (or approximately 1% of the population). Its pan-Canadian COVID-19 Antibody Study will now collect a second dried blood spot sample from over 20,000 Canadians, aged 30 and older. Researchers will test the samples for presence and level of antibodies to SARS-CoV-2, produced in response to either vaccination or past infection with the novel coronavirus. Please click here for additional details: https://bit.ly/3I6lWE5