New environmental exposure data added to CanPath: Greenness, air quality, and accessibility

CanPath is excited to continue collaborating with the CIHR-funded Canadian Urban Environmental Health Research Consortium (CANUE) by linking a third round of environmental exposure data to the national harmonized CanPath datasets. Since 2016, CANUE has gathered and standardized environmental exposure data on air and noise pollution, land use, community amenities, green spaces, climate, and socioeconomic conditions. This data is then linked to Canadian cohort studies and health databases. CANUE and CanPath conducted their first linkage activity in May 2019, followed by a second round of linkage in June 2021. The CANUE environmental exposure data was merged with CanPath’s national harmonized datasets using participants’ 6-digit residential postal codes and are available to researchers. This year, 17 new datasets were added to the existing 27 environmental exposure datasets, providing additional measures of greenness, air quality, accessibility, and socioeconomic factors. “The key strength of CanPath’s collaboration with CANUE is the wide-ranging environmental exposures captured, allowing for diverse analyses beyond disease prevention, including developing healthier environments,” says Sheraz Cheema, CanPath Data Manager. “This longitudinal data is invaluable for researchers assessing prolonged exposure impacts on health. CanPath aims to continue collecting data for 20-30 years, increasing its value over time.” Green spaces and vegetation CANUE develops data on neighbourhood greenness from two main sources. First, the MODIS satellite program has provided a consistent measure of greenness across Canada from 2000 to 2023, using a single sensor to ensure data reliability at a 250-meter resolution. Greenness is measured using the Normalized Difference Vegetation Index (NDVI) scale to characterize an area’s vegetation density. Secondly, the Landsat-based Vegetative Greenness Fractions dataset offers a finer 30-meter resolution and measures greenness. This dataset can even detect roads and buildings beneath tree canopies, offering a more detailed view. “This could be an excellent opportunity to study those vertical layers,” says Joey Syer, CANUE Data Director, “as opposed to just the horizontal layer of greenness.” New datasets linked to CanPath include: Advanced Very High-Resolution Radiometer (AVHRR) Normalized Difference Vegetation Index (NDVI) (2000-2013) Landsat – Greenest Pixel (2000-2017) Landsat – Growing Season (2000-2019) Moderate Resolution Imaging Spectroradiometer (MODIS) – Annual Max (2000-2023) MODIS – Annual Mean (2000-2023) MODIS – Growing Season Max (2000-2023) MODIS – Growing Season Mean (2000-2023) Air quality One of the relatively new datasets in CANUE’s data holdings is the Canadian Optimized Statistical Smoke Model (CanOSSEM), which Naman Paul and colleagues developed at the BC Centre for Disease Control. This dataset estimates fine particulate matter (PM2.5) and is optimized for wildfire smoke. CANUE has data from 2010 to 2022 at daily, monthly, and annual scales, and it comes on a 5 km by 5 km grid. “The variation within those five kilometres is probably not much,” says Joey, “but the fact that this data covers all of Canada makes this an unparalleled resource in terms of space and time attributes. It’s really deserving of usage and study.” New datasets include: Fine Particulate Matter (PM2.5 v4) (2000-2020) Fine Particulate Matter (PM2.5 v5) (2000-2021) Smoke Exposure (PM2.5 v2) (2010-2022) Accessibility and transportation The CanPath data assets have also been updated with many new datasets in the ‘neighbourhoods’ domain. These include the Canadian Bikeway Comfort and Safety Classification System (Can-BICS) metrics, which measure the quantity and quality of cycling infrastructure in Canadian communities, and several spatial accessibility indicators, which provide information on access to different services and amenities. “By linking these and other CANUE datasets to CanPath data, we can explore how the built environment affects chronic health conditions like never before,” says Dr. Dany Doiron, CANUE Managing Director. New datasets include: Spatial Accessibility Measures (2021) Public Transportation (2019) Canadian Bikeway Safety Metrics (Can-BICS) (2021) Street Connectivity (2019) Other socioeconomic factors Many other socioeconomic factors can provide valuable insights into how the built environment and access to healthy food impact chronic diseases, including cancer risk and prevention. Dr. Trevor Dummer, CanPath National Scientific Co-Director, spoke about his role as a health geographer: “My interest in cancer prevention is understanding how the built environment and natural environment influences our cancer risk. This includes how our behaviours, such as physical activity or access to healthy food, are impacted by our geography. CanPath, as a longitudinal cohort linked to CANUE geospatial information and cancer registry data, has vast potential for epidemiological analysis to identify cancer risk factors and support prevention.” New datasets include: Building Density (2019) Dwellings Needing Repair (2016-2021) Canadian Food Environment Dataset (Can-FED) (2018)

Got Your Toe(nails)! Guinness World Record Revisited

The Guinness World Records team is once again reflecting on the record held by the Atlantic PATH cohort. In a new article, “Got your toe(nails)! Scientific study holds largest collection of toenail clippings,” Katherine Gross revisits the collection of toenail samples from Atlantic PATH participants. In 2013, Atlantic PATH received a Guinness Book of World Records for 24,999 toenail samples. Recruitment continued until 2015 and the total number of participants who donated toenails was 30,418!! Atlantic PATH represents participants across Nova Scotia, New Brunswick, Prince Edward Island, and Newfoundland and Labrador, a region with the highest rates of cancer and chronic disease in the country. “Toenails are an important part of our research….What we’re particularly interested in, in this context, is the extent to which environmental exposure affects our risk of disease.” Atlantic PATH has used data and biological samples to develop an established environmental and occupational health research stream. Stay tuned for more toenail research that is currently in progress, and you can find recent publications here: Hood, K., Sweeney, E., Ilie, G., Keltie, E., Kim, J.S. (2023), Toenail Arsenic Species and Metallome Profiles Associated with Breast, Cervical, Prostate, and Skin Cancer Prevalence in the Atlantic Partnership for Tomorrow’s Health Cohort. Frontiers in Public Health: Environmental health and Exposome, 11. https://doi.org/10.3389/fpubh.2023.1148283 Smith, N.K., Keltie, E., Sweeney, E., Weerasinghe, S., MacPherson, K., Kim, J.S. (2022). “Investigating the Association between Arsenic Exposure and Chronic Disease Using Toenail Speciation Biomarkers: A Feasibility Study.” Ecotoxicology and Environmental Safety.   https://doi.org/10.1016/j.ecoenv.2022.113269 Keltie, E.; Cui, Y.; Hood, K.; Sweeney, E.; Ilie, G.; Adisesh, A.; Dummer, T.; Kim, J.S. (2022). “The Association of Prostate Cancer with the Profiles of Arsenic Species and Metallome: An Analysis from the Atlantic PATH Cohort Study.” Frontiers in Public Health, Environmental Health and Exposome.   https://doi.org/10.3389/fpubh.2022.818069 Majouni, S., Kim, J.S., Sweeney, E., Keltie, E., Abidi, S. (2022). Applying Machine Learning to Arsenic Species and Metallomics Profiles of Toenails to Evaluate Associations of Environmental Arsenic with Incident Cancer Cases. Medical Informatics Europe Conference (MIE) Conference Proceedings. Studies in Health Technology and Informatics. Fleming, D., Crook, S., Evans, C., Nader, M., Atia, M., Hicks, J., Sweeney, E., McFarlane, C., Kim, J.S., Keltie, E., Adisesh, A. (2020). “Assessing arsenic in human toenail clippings using portable X-ray fluorescence.” Applied Radiation and Isotopes. https://doi.org/10.1016/j.apradiso.2020.109491 Fleming, D., Crook, S., Evans, C., Nader, M., Atia, M., Hicks, J., Sweeney, E., McFarlane, C., Kim, J.S., Keltie, E., Adisesh, A. (2020). “Portable X-ray Fluorescence of Zinc Applied to Human Toenail Clippings.” Journal of Trace Elements in Medicine and Biology. https://doi.org/10.1016/j.jtemb.2020.126603 Dummer, T., Yu, Z.M., Nauta, L., Murimboh, J., Parker, L. (2015). “Geostatistical modelling of arsenic in drinking water wells and related toenail arsenic concentrations across Nova Scotia, Canada.” Science of the Total Environment, 505. https://doi.org/10.1016/j.scitotenv.2014.02.055 Yu, Z.M., Dummer, T., Adams, A., Murimboh, J., Parker, L. (2014). “Relationship between drinking water and toenail arsenic concentration among a cohort of Nova Scotians.” Journal of Exposure Science and Environmental Epidemiology, 24. https://doi.org/10.1038/jes.2013.88 Yu, Z.M, Fung, B., Murimboh, J., Parker, L., Dummer, T. (2014). “What is the role of obesity in the aetiology of arsenic-related disease?” Environment International, 66.  http://dx.doi.org/10.1016/j.envint.2014.01.028  

Upcoming Webinar – CanPath Trainees Study Pollution and Disease

Hybrid event: From air to ailment: trainees study pollution’s role in disease onset December 10, 2024 @ 1pmAST/12pmEST Registration: https://www.eventbrite.ca/e/from-air-to-ailment-trainees-study-pollutions-role-in-disease-onset-tickets-1080426387409 Are you curious about how environmental factors like air pollution affect our health? Join us for an engaging event where four MPH in Epidemiology students from the Dalla Lana School of Public Health (DLSPH) share their cutting-edge research conducted during their summer practicum at CanPath. Discover how Fatima investigates the link between air pollution and endometriosis, Natalie explores its impact on inflammatory bowel diseases, Emilia examines connections to cardiometabolic conditions, and Taryn studies the association with early-onset type II diabetes mellitus. Their findings provide new insights into the complex relationship between air quality and chronic diseases, highlighting the importance of environmental health research. This event is a must-attend for trainees and early-career researchers interested in epidemiology, public health, and environmental sciences. Gain valuable knowledge, network with peers, and get inspired by the innovative work of your fellow researchers.

#PlaidForDad2023

#PlaidForDad2023 — Prostate Cancer Awareness and Research Atlantic PATH welcomes our youngest team member(!) and continues the Plaid for Dad tradition raising awareness about prostate cancer in Canada. We have ongoing research on prostate cancer exploring environmental exposure to arsenic and cancer risk using toxicological and machine learning methods. This research stream has received and benefitted from funding from Nova Scotia Health, the Beatrice Hunter Cancer Research Institute, Prostate Cancer Canada, the Canadian Cancer Society, and the New Frontiers in Research Fund.  Related publications to date include: Keltie, E., Hood, K., Cui, Y., Sweeney, E., Ilie, G., Adishesh, A., Dummer, T.J.B., Bharti, V., Kim, J.S. (2022). Arsenic speciation and metallomics profiling of human toenails as a biomarker to assess prostate cancer cases: Atlantic PATH cohort study. Frontiers in Public Health, 10.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301242/ Hood, K., Sweeney, E., Ilie, G., Keltie, E., Kim, J.S. (2023). Toenail arsenic species and metallome profiles associated with breast, cervical, prostate, and skin cancer prevalence in the Atlantic Partnership for Tomorrow’s Health cohort. Frontiers in Public Health, Environmental Health and Exposome.  https://www.frontiersin.org/articles/10.3389/fpubh.2023.1148283/full Smith, N., Keltie, E., Sweeney, E., Weerasinghe, S., MacPherson, K., Kim, J.S. (2022). Toenail speciation biomarkers in arsenic-releated disease: a feasibility study for investigating the association between arsenic expsosure and chronic disease. Ecotoxicology and Environmental Safety, 232. https://www.sciencedirect.com/science/article/pii/S0147651322001099 We have also conducted research on the mental health of prostate cancer survivors compared to those with no history of cancer and those with types of cancer. This work was supported by funding from the Beatrice Hunter Cancer Research Institute. Publications to date include: Ilie, G., Rutledge, R., Sweeney, E. (2020). Anxiety and depression symptoms in adult males in Atlantic Canada with or without a lifetime history of prostate cancer. Psycho-Oncology. https://onlinelibrary.wiley.com/doi/10.1002/pon.5244 Ilie, G., Rutledge, R., Sweeney, E. (2021). An examination of the role of socioeconomic status in the relationship between depression and prostate cancer survivorship in a population-based sample of men from Atlantic Canada. Oncology, 99(4). https://pubmed.ncbi.nlm.nih.gov/33486485/ Ilie, G., Rutledge, R., Sweeney, E. (2021). Post-Treatment Adverse Health Correlates among Prostate Cancer Survivors in a Sample of Men Residing in Atlantic Canada. Current Oncology, 28(4). https://www.mdpi.com/1718-7729/28/4/246