Post-Treatment Adverse Health Correlates among Prostate Cancer Survivors in a Sample of Men Residing in Atlantic Canada

Title: Post-Treatment Adverse Health Correlates among Prostate Cancer Survivors in a Sample of Men Residing in Atlantic Canada Journal: Current Oncology Authors: Gabriela Ilie, Rob Rutledge and Ellen Sweeney Abstract: Background: Recent large population-based studies have shed light on an association between prostate cancer (PCa) survivorship and mental health, which emerged when the comparison group was either men without a history of cancer or those with any other type of cancer except prostate. Here we examine the role of surgery alone, compared to other types of treatment modalities in this association in a population-based sample of men with prostate or other types of cancer. Methods: A cross-sectional analysis was conducted on a subsample of 632 male participants aged 36–69 from the 2009–2015 survey cycle of the Atlantic PATH cohort study. The primary outcomes were the presence of mild, moderate or severe depression or anxiety indicators and were assessed using the seven-item generalized anxiety disorder (GAD-7) scale and the nine-item Patient Health Questionnaire (PHQ-9), respectively. The presence of a lifetime history of PCa or other form of cancer (except PCa) was the main predictor variable and was assessed in cancer treatment modality (surgery or other types of treatment modalities) stratified analyses. Covariates included age, marital status, household income, comorbidity, and survivorship time. Results: The presence of depression in this sample was prevalent among 17.7% of men, and of anxiety among 9.3% of men. Survivors who were treated with surgery for their PCa diagnosis had 7.55 statistically significantly higher odds of screening positive for current depression symptoms compared with those of other forms of cancer in controlled analyses. These differences were not observed for anxiety. Conclusions: These findings emphasize the need for multidisciplinary survivorship care plans among PCa patients, especially those who undergo surgery. Targeted programming aimed at prioritizing and delivering comprehensive mental health support to PCa survivors early in the survivorship journey is justified. https://doi.org/10.3390/curroncol28040246

Environmental Correlates of Physical Activity, Sedentary Behavior, and Self-Rated Health in Chronic Obstructive Pulmonary Disease

Journal: Journal of Cardiopulmonary Rehabilitation and Prevention Authors: Daniel Stevens, Pantelis Andreou, Daniel Rainham Abstract : Purpose: Physical activity (PA) predicts important health outcomes in chronic obstructive pulmonary disease (COPD). In the general population, environmental factors have the potential to influence PA; however, data are limited in this clinical population. Therefore, we sought to investigate associations between the environment and PA, sedentary behavior, and self-rated health in COPD. Methods: Sociodemographic, PA, sedentary behavior, and self-rated health data were collected from a prospective cohort of 418 individuals with COPD (65% female; 58 ± 8 yr), while environmental data were drawn from a national environmental data repository and individually matched to participant postal code. Environmental variables included social and material deprivation, urban form index, surrounding greenness, and air quality (concentrations of air pollution for fine particles, nitrogen dioxide, ozone, and sulphur dioxide). Logistic and multivariate linear regression models were used to investigate the strongest environmental predictors. Results: The models showed a statistically significant negative correlation between PA level and ozone pollution (P = .023; adjusted OR = 0.85: 95% CI, 0.74-0.98). Urban form index was also significantly associated with sedentary behavior (β = 0.113; t value = 1.71; P = .011). Self-rated health was significantly positively correlated with PA level (P = .006; adjusted OR = 2.22: 95% CI, 1.25-3.94), and significantly inversely correlated with sedentary behavior (β = −0.159; t value =−2.42; P = .016). Conclusion: These new data may identify barriers to PA and assist clinicians in the prescription of exercise for individuals living with COPD. doi: 10.1097/HCR.0000000000000628

New Publication: Environmental Correlates of Physical Activity, Sedentary Behavior, and Self-Rated Health in Chronic Obstructive Pulmonary Disease

Congratulations to Dr. Daniel Stevens, Dr. Pantelis Andreou and Dr. Daniel Rainham on their publication on environmental correlates of physical activity, sedentary behaviour and self-rated health in chronic obstructive pulmonary disease (COPD) in the Journal of Cardiopulmonary Rehabilitation and Prevention. https://bit.ly/2Vi6FvO

New Publication: Age and Sex-Specific Associations in Health Risk Factors for Chronic Disease

We’re happy to share a new article from Dr. Vanessa DeClercq & Dr. Ellen Sweeney on the age- & sex-specific associations in health risk factors for chronic disease in the Atlantic PATH cohort. They found that there are evident differences in health risk factors for males and for females, as well as across age groups, and public health efforts need to account for the role played by sex and age in addressing chronic disease burden in Canadian adults. https://bit.ly/36UxHMx

Age and Sex-Specific Associations in Health Risk Factors for Chronic Disease: Evidence from the Atlantic Partnership for Tomorrow’s Health (PATH) Cohort

Title: Age and Sex-Specific Associations in Health Risk Factors for Chronic Disease: Evidence from the Atlantic Partnership for Tomorrow’s Health (PATH) Cohort Journal: Canadian Journal on Aging Authors: Vanessa DeClercq and Ellen Sweeney Abstract: The objective of this study was to discern health risk factors for chronic disease by age and sex in a Canadian cohort. Participants of the Atlantic Partnership for Tomorrow’s Health (PATH) cohort with health risk factor data (physical activity, smoking, alcohol consumption, diet, body mass index [BMI]) were included (n = 16,165). Multivariable logistic regression models were used to evaluate the relationship among health risk factors, age, and sex. Regression analysis revealed that the odds of engaging in high levels of physical activity and having a BMI ≥ 25 was lower for females than males across all age groups, whereas the odds of abdominal obesity was substantially higher for females of all ages than for males. The odds of habitually consuming alcohol was lower for females of all ages than for males, and the odds of being a former/current smoker was lower for older (57–74 years of age) females than for males. The odds of consuming five or more servings of fruit and vegetables per day was higher for females of all ages than for males. There are evident differences in health risk factors for males and for females, as well as across age groups, and public health efforts need to account for the role played by sex and age in addressing chronic disease burden in Canadian adults.

Shift Work and Mental Health: Findings from a new Atlantic PATH study

We are pleased to announce the latest in our research on Atlantic PATH shift workers! Sweeney et al. (2021) evaluated the relationship between mental health and shift work in a matched study with 12,413 participants, including 4155 shift workers and 8258 non-shift workers. Shift workers were more likely to have increased rates of depression and poor self-rated health, as well as depressive and anxiety symptom scores compared to non-shift workers. The full article can be found free for 50 days compliments of Elsevier – https://authors.elsevier.com/a/1dMIjKt2p%7EjIi This research builds on our previous work that found an increased risk of cardiovascular disease, obesity and diabetes among shift workers, despite higher levels of physical activity and lower levels of sedentary behaviour (https://bit.ly/2TJEoxN).    

The association between mental health and shift work: Findings from the Atlantic PATH study

Journal: Preventive Medicine Authors: Ellen Sweeney, Yunsong Cui, Zhijie Michael Yu, Trevor JB Dummer, Vanessa DeClercq, Cynthia Forbes, Scott A Grandy, Melanie R Keats, Anil Adisesh Abstract We evaluated the relationship between mental health and shift work in the Atlantic Partnership for Tomorrow’s Health (PATH) cohort study. In a matched study with 12,413 participants, including 4155 shift workers and 8258 non-shift workers, we utilized general linear models and logistic regression models to assess the differences in depression, anxiety, and self-rated health. Shift workers reported higher levels of each of the mental health-related domains compared to non-shift workers. There was a significant increased risk of depression (OR = 1.13, 95% CI, 1.00–1.27) and poor self-rated health (OR = 1.13, 95% CI, 1.14–1.55) among shift workers compared to non-shift workers. Shift workers were more likely to have increased rates of depression and poor self-rated health, as well as depressive and anxiety symptom scores compared to non-shift workers. As a result, shift workers may be at increased risk of comorbidity, poor quality of life, missed work, and early retirement.   Doi: https://doi.org/10.1016/j.ypmed.2021.106697

Early results from CanPath’s national study confirm antibody levels are stronger after receiving two doses of COVID-19 vaccine

Initial preliminary results from the Canadian Partnership for Tomorrow’s Health (CanPath) COVID-19 Antibody Study, based on close to 6,000 dried blood spot samples collected between February 8 and May 17, 2021, show a high degree of variability in the level of antibodies produced by a single dose of a COVID-19 vaccine. These findings highlight the importance of accelerating second doses as the Delta variant continues to spread, particularly with the vast majority of Canadians having received only a single vaccine dose. This is the first pan-Canadian study using samples from a wide range of participants to confirm evidence from vaccine manufacturers’ clinical trials, as well as findings in a recent preprint from the United Kingdom and other smaller studies.   Participants from Atlantic PATH, CARTaGENE, the Ontario Health Study, Manitoba Tomorrow Project, Alberta’s Tomorrow Project, and BC Generations contributed to the COVID-19 Antibody Study. https://bit.ly/3gVLeb2  

New Frontiers in Research Fund 2020 Exploration Grant

Atlantic PATH is thrilled to be involved in the newly funded project led by Dr. Juliet Daniel at McMaster University. The New Frontiers in Research Fund 2020 Exploration grants target high-risk, high-reward and interdisciplinary research. This work will focus on disparities in cancer incidence and outcomes in a Black Nova Scotian community (Shelburne, Nova Scotia). This research is truly interdisciplinary, incorporating natural and social sciences to consider the role of environmental, biological, genetic, socioeconomic, and lifestyle factors with the high cancer incidence and mortality in this community. We’re pleased to be working with our Dalhousie University colleagues, Dr. Ingrid Waldron (School of Nursing), Dr. Jong Sung Kim (Faculty of Medicine), Dr. Paola Marignani (Faculty of Medicine) and Dr. Charles Hostovsky (School of Planning).   https://bit.ly/3fHw3CU  

CanPath Student Dataset

CanPath has developed a Student Dataset that provides students the unique opportunity to gain hands-on experience working with CanPath data. The CanPath Student Dataset is a synthetic dataset that was manipulated to mimic CanPath’s nationally harmonized data but does not include or reveal actual data of any CanPath participants. The CanPath Student Dataset is available to instructors at a Canadian university or college for use in an academic course, at no cost. CanPath will provide the Student Dataset and a supporting data dictionary. Advantages of the CanPath Student Dataset: Large sample size (Over 40,000 participants) Real-world population-level Canadian data Variety of areas of information allowing for a wide range of research topics No cost to faculty Potential for students to apply for real CanPath data to publish their findings For additional details, please see: https://canpath.ca/student-dataset/